There has been a great need to develop a research agenda to strengthen mental health and psychosocial support in humanitarian settings; prior research in this area has had limited inputs from practitioners. The authors developed a consensus-based research agenda for the next ten years through inputs from an interdisciplinary group of academics, policy makers, and practitioners representing regions where humanitarian crises occur, published in PloS Medicine. The ten most highly prioritized research questions consisted of questions related to problem analysis, mental health and psychosocial support interventions, research and information management, and mental health and psychosocial support context.